It is by far known that medicines are integral components of a health care system. Although there are immense active pharmaceutical entities in the global market, limiting medicines that shall be used within a given health institution is advantageous for proper management of medicine with in a facility. This is done with due regard to factors like; safety, efficacy, quality, cost- benefit ratio, indication for treatment of diseases which is prominent in health center, sufficient experience with the medicines, health professional available in the facility and other factors. Pharmaco therapeutics classification of medicine was utilized to categories medicines for the health center. After five years of use, the second edition of the List of Medicines for health center is now revised in light of the latest development in the fields of medicine and pharmacy besides to this the Authority included some of medication which was requested to be included in the second edition. As customary, the purpose of the third edition of List of Medicine for health center is to provide up-to-date list of medicine for the health center, to improve procurement, to increase availability and to promote proper use of Medication. The draft of the revised edition was first prepared by the Authority using a technical working group composed of General practitioners, a nurse and pharmacists and then enriched through national consultative workshops. Participants involved in the workshops were specialists and other health professionals from various disciplines. i.e. Nursing, Pharmacy, Cardiology, Dentistry, Dermatology, ENT, Internal Medicine, Neurology, Obstetrics & Gynecology, Oncology, Ophthalmology, Pediatrics, Psychiatry and Surgery; representatives of teaching institutions, professional associations, regional health bureaus, relevant departments of Ministry of Health, pharmaceutical manufacturers & importers, government hospitals and other related organizations Soon after, the revised version of List of Medicine for health center was finalized by the National Drug Advisory Committee. In the course of reviewing the previous edition, medicines which are obsolete, less effective, with low benefit to risk ratio and superseded by better ones have been deleted while medicines with better quality, safety and efficacy profile have been included. Except for the addition of some new categories, the pharmacotherapeutic classification system that was used in the previous edition is still maintained. Consequently, all users of this list are strongly invited to send their comments and suggestions to the Food, Medicine and Healthcare Administration and Control Authority of Ethiopia,