Training was given to six health centers of yeka sub city on pharmacovigilance from January 22 to the end of March 2016. Wereda 8/Chefe Health center (HC), Wereda 12 HC, Entoto no 2 HC, and Ferensay Akababi HC. A total of 176 health providers were trained on the limitations of premarketing evaluations ,the importance of pharmacovigilance, the national pharmacovigilance system mandates and responsibilities, the three types of ADE reporting mechanisms, medication error and its prevention mechanisms and the role of Drug and Therapeutic Committee in assessing and managing drug safety. ADE reporting form, newsletters and an allergy card was distributed during the discussions to be used during and after the training. Detail explanation of what to report ,how to report ,when to report and to whom to report an adverse event was discussed with the participants. Different varieties of challenges encountered in reporting were raised and discussed by the participants. Each facility assigned a focal person after the trainings for further follow up and strengthen the relation ship between the facility and the pharmacovigilance center in the country.