Proper medicines use including rational prescribing, rational despensing and proper administration of medicines by the patient’s is important in the health of the public. Defining the patient’s problems, setting therapuetic objectives and proper comuniction with patients promots rational use of medicines which eventually help to reduces harm to the health of each indivuduals and the effects on the overall health-care delivery service. Surely, medicines should be prescribed and despensed only when the benefits outweigh the risks to the individual patient. In Ethiopia, as the health service expands quite rapidly, medicines information resources needs to be made available and accessible at equal pace. In relation to this the government recognizes the unmet need on medicines information and has been striving to develop and make accessible information using different mechanisms. As a result, it is our pleasure to introduce and provide all beneficiaries this comprehensive Rural Drug Vender Formulary (RDVF) The Formulary aims to provide standard information on medicines and to help health professionals base their practice on solid information and knowledge to promote rational use of medicines. The formulary contains detailed information on each pharmacotherapeutic class of drugs and specific information for each drugs including indication, caution, drug interaction, contraindication, side effect, dose and administration and information on storage condition. The formulary also contains general notes on good prescribing and dispensing practices, and other necessary information.